Vulnerability of mesostriatal dopaminergic neurons in Parkinson’s disease
نویسندگان
چکیده
منابع مشابه
Vulnerability of Mesostriatal Dopaminergic Neurons in Parkinson's Disease
The term vulnerability was first associated with the midbrain dopaminergic neurons 85 years ago, before they were identified as monoaminergic neurons, when Foix and Nicolesco (1925) reported the loss of neuromelanin containing neurons in the midbrain of patients with post-encephalitic Parkinson's disease (PD). A few years later, Hassler (1938) showed that degeneration is more intense in the ven...
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The mesostriatal dopaminergic system, which comprises the mesolimbic and the nigrostriatal pathways, plays a major role in neural processing underlying motor and limbic functions. Multiple reports suggest that these processes are influenced by hemispheric differences in striatal dopamine (DA) levels, DA turnover and its receptor activity. Here, we review studies which measured the concentration...
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Parkinson disease (PD) is characterized by the specific degeneration of dopaminergic (DA) neurons in substantia nigra and has been linked to a variety of environmental and genetic factors. Rotenone, an environmental PD toxin, exhibited much greater toxicity to DA neurons in midbrain neuronal cultures than to non-DA neurons. The effect was significantly decreased by the microtubule-stabilizing d...
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This objective of this study is how grammar is implemented in the brain, with special attention to a neurotransmitter dopamine. Among numerous kinds of molecules known to exist in the nervous system, several molecules are known to function as “neurotransmitters”, which mediate gaps between neurons (i.e., synapses) when a neuron transmits signals to another. In this study, a neurotransmitter dop...
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ژورنال
عنوان ژورنال: Frontiers in Neuroanatomy
سال: 2010
ISSN: 1662-5129
DOI: 10.3389/fnana.2010.00140